Differential induction of reactive oxygen species through Erk1/2 and Nox-1 by FK228 for selective apoptosis of oncogenic H-Ras-expressing human urinary bladder cancer J82 cells

Oncogenic H-Ras, FK228, and exogenous H2

Oncogenic H-Ras, FK228, and exogenous H2O2 cooperatively activated the erk pathway in selective induction of human urinary bladder cancer j82 cell death

✍ Shambhunath Choudhary; Kwo-Kwang Abraham Wang; Hwa-Chain Robert Wang 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 179 KB

More than 35% of human urinary bladder cancers involve oncogenic H-Ras activation. The goal of this study was to investigate the role of the ERK pathway in mediating apoptotic signals induced by oncogenic H-Ras, FK228 treatment, and exogenous H 2 O 2 treatment to increase Nox-1 elevation, leading to