Differential Impact of Resistance-Associated Mutations to Protease Inhibitors and Nonnucleoside Reverse Transcriptase Inhibitors on HIV-1 Replication Capacity
✍ Scribed by Hsieh, Szu-Min; Pan, Sung-Ching; Chang, Sui-Yuan; Hung, Chien-Ching; Sheng, Wang-Huei; Chen, Mao-Yuan; Chang, Shan-Chwen
- Book ID
- 120216174
- Publisher
- Mary Ann Liebert
- Year
- 2013
- Tongue
- English
- Weight
- 394 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0889-2229
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## Abstract An extended spectrum of HIV‐1 reverse‐transcriptase (RT) mutations in HAART‐treated patients has been recently described. To verify the possible association of previously unreported RT mutations with a decrease of phenotypic susceptibility to nucleoside (NRTIs) and non‐nucleoside (NNRTI
The emergence of genotypic resistance in protease and reverse transcriptase (RT) gene regions was longitudinally evaluated in plasma samples from a group of 12 HIV-1-infected patients treated with different combination of antiretroviral therapies and selected on the basis of their clinical failure.