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Differential impact of apolipoprotein E genotype on distributions of amyloid load and glucose metabolism in Alzheimer's disease

✍ Scribed by Van der Flier, Wiesje; Ossenkoppele, Rik; Adriaanse, Sofie; Zwan, Marissa; Boellaard, Ronald; Windhorst, Albert; Barkhof, Frederik; Scheltens, Philip; Lammertsma, Adriaan; van Berckel, Bart

Book ID: 122364544
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 58 KB
Volume: 8
Category: Article
ISSN: 1552-5260
DOI: 10.1016/j.jalz.2012.05.1646

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Objective: To study the effect of apolipoprotein E 4 status on biomarkers of neurodegeneration (atrophy on magnetic resonance imaging [MRI]), neuronal injury (cerebrospinal fluid [CSF] t-tau), and brain A␤ amyloid load (CSF A␤ 1-42 ) in cognitively normal subjects (CN), amnestic subjects with mild c