✦ LIBER ✦

Differential gene expression in neural stem cells and oligodendrocyte precursor cells: A cDNA microarray analysis

✍ Scribed by Jian-Guo Hu; Sai-Li Fu; Kai-Hua Zhang; Ying Li; Lan Yin; Pei-Hua Lu; Xiao-Ming Xu

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 390 KB
Volume: 78
Category: Article
ISSN: 0360-4012
DOI: 10.1002/jnr.20317

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The use of neural stem cells (NSCs) or their progeny oligodendrocyte precursor cells (OPCs) represents a promising repair strategy for many neurological disorders. However, the molecular events and biological features during the transition from NSCs to OPCs remain unclear. In the present study, we isolated NSCs from the embryonic rat forebrain and induced them into OPCs by using B104 conditioned medium (B104CM) in vitro. We then employed cDNA array technology to compare changes in gene expression between the two cell populations. Among 1,176 genes examined, 40 were differentially expressed, and some of them may be involved in OPC differentiation from NSCs. Our findings thus provide new insights into the molecular basis of differentiation of OPCs from NSCs. © 2004 Wiley‐Liss, Inc.

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