Using in vivo selection methods, we obtained metastatic sublines of the murine RAW117 large cell lymphoma that form multiple liver metastases. The highly metastatic subline RAW117-H10 has a low number of gp70 molecules expressed at the cell surface and low cytostatic sensitivity to activated syngene
Differential gene expression in murine large cell B-cell lymphoma metastatic variants
β Scribed by Shantaram S. Joshi; Amit K. Mittal; Peng Wang; Avadhut D. Joshi; Eileen Vu; Xioujun Wang
- Book ID
- 116576382
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 304 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1567-5769
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π SIMILAR VOLUMES
A metastatic variant cell subline of the Abelson virus-transformed murine large lymphoma/lymphosarcoma RAW117 has been selected in vivo ten times for liver colonization. Highly metastatic subline RAW117-H10 forms greater than 200 times as many gross surface liver tumor nodules as the parental line R
Metastatic variant sublines of the murine RAW117 large cell lymphoma or lymphosarcoma have been established in vitro by sequential cycles of harvesting of liver tumor nodules after intravenous inoculation of tumor cell suspensions into syngeneic BALB/c mice. After five and ten in vivo selections for