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Differential gene expression in leiomyosarcoma

✍ Scribed by Keith M. Skubitz; Amy P. N. Skubitz

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
382 KB
Volume
98
Category
Article
ISSN
0008-543X

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✦ Synopsis

Abstract

BACKGROUND

Leiomyosarcomas (LMS) are a common subtype of soft tissue sarcoma. The molecular causes of the disease remain unclear.

METHODS

In the current study, gene expression in LMS, leiomyomas, and normal myometrium was examined. RNA was prepared and gene expression was determined using microarray analysis arrays containing approximately 12,000 known genes and 48,000 expressed squence tags (ESTs).

RESULTS

A number of genes were found to be differentially expressed in these sample sets, and six genes including cyclin‐dependent kinase inhibitor 2A, diaphanous (Drosophila homolog) 3, doublecortin, calpain 6, interleukin‐17B, and proteolipid 1 were found to be overexpressed in LMS compared with normal myometrium and 18 other tissues. Sets of genes were identified whose expression could be used to cluster samples with either LMS, leiomyomas, or normal myometrium.

CONCLUSIONS

The authors concluded that differences in gene expression can be detected between LMS and leiomyomas, normal myometrium, and other tissues, and that these changes in gene expression may yield clues with regard to the pathophysiology of leiomyosarcoma. Cancer 2003;98:1029–38. Β© 2003 American Cancer Society.

DOI 10.1002/cncr.11586

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