Differential function of MAP2, MAP2C and tau on the organization of microtubules in the cells
β Scribed by Chen, Jianguo; Kanai, Yoshimitsu; Hirokawa, Nobutaka
- Book ID
- 123166771
- Publisher
- Elsevier Science
- Year
- 1992
- Weight
- 128 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0921-8696
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Microtubules serve as transport tracks in molecular mechanisms governing cellular shape and polarity. Rapid transitions between stable and dynamic microtubules are regulated by several factors, including microtubule-associated proteins (MAPs). We have shown that MAP/microtubule affinity regulating k
It is well documented that the MAPs, MAP2 and tau, play pivotal roles in neurite outgrowth. Several isoforms of MAP2 and tau are coexpressed in neurons, suggesting that the pattern of neurite outgrowth results from a functional equilibrium among these isoforms. In the present study, by coexpressing