Differential expressions of the eph family of receptor tyrosine kinase genes (sek, elk, eck) in the developing nervous system of the mouse
β Scribed by Tetsuji Mori; Akio Wanaka; Akihiko Taguchi; Kazumasa Matsumoto; Masaya Tohyama
- Book ID
- 119138823
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 817 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0169-328X
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In a search for novel tyrosine kinases involved in vertebrate development, we have isolated cDNAs corresponding to three distinct members of the Eph-family of receptor tyrosine kinases. Whole mount RNA in situ hybridization analysis showed all three genes were most abundantly expressed in the develo
## Abstract Ephrins and Eph receptors are a family of molecules that have been implicated in axonal pathfinding. A unique feature of Bβclass ephrins and Eph receptors is their ability to transmit bidirectional signals in both ephrinβ and Eph receptorβexpressing cells upon cellβcell contact. These s