Differential expression patterns of mRNAs for members of the fibroblast growth factor receptor family, FGFR-1–FGFR-4, in rat brain

✍ Scribed by N. Yazaki; Y. Hosoi; K. Kawabata; A. Miyake; M. Minami; M. Satoh; M. Ohta; T. Kawasaki; N. Itoh

• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: English
• Weight: 865 KB
• Volume: 37
• Category: Article
• ISSN: 0360-4012
• DOI: 10.1002/jnr.490370403

✦ Synopsis

We have examined the region-specific expression of mRNAs for four members of rat FGF receptor family, FGFR-1, FGFR-2 FGFR-3, and FGFR-4, in rat brain by in situ hybridization. The FGFR-1, FGFR-2, and FGFR-3 mRNAs were expressed widely but differentially in the brain. However, the FGFR-4 mRNA was not expressed in the brain. The FGFR-1 mRNA was strongly expressed in several regions including the hippocampus, cerebellum, and pedunculopotine tegmental nucleus. The FGFR-2 mRNA expression was high in the choroid plexus, and moderate in the fiber-rich regions (the corpus callosum, external capsule, and internal capsule) and the olfactory bulb. The FGFR-3 mRNA was expressed diffusely in the brain. We have also examined the cellular localization of these mRNAs in the brain. Although the FGFR-1 mRNA was expressed preferentially in neurons, the FGFR-2 and FGFR-3 mRNAs were expressed preferentially in glial cells. The present findings that the FGFR-1, FGFR-2, and FGFR-3 mRNAs were expressed widely but with region-and cell-specificity in the brain indicate that these receptors have different roles in the brain.