Differential expression of the regulator of G protein signaling RGS9 protein in nociceptive pathways of different age rats
โ Scribed by Ki Jun Kim; Kumi Moriyama; Kyung Ream Han; Manohar Sharma; Xiaokang Han; Guo-xi Xie; Pamela Pierce Palmer
- Book ID
- 113567211
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 657 KB
- Volume
- 160
- Category
- Article
- ISSN
- 0165-3806
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A clone of the regulator of G-protein signalling, RGS9, was isolated from a rat striatum-minus-cerebellumminus-hippocampus subtracted library generated by directional tag polymerase chain reaction subtraction. The full-length cDNA clone encodes a 444 amino acid protein containing an 118 amino acid R
## Abstract Regulator of Gโprotein signalingโ2 (RGSโ2) belongs to a novel family of GTPaseโactivating proteins that rapidly turnโoff Gโprotein coupled receptor signaling. RGS proteins contain a characteristic RGS domain by which they interact with the ฮฑโsubunit of Gโproteins and drive them into the