Differential expression of osteopontin and bone sialoprotein in bone metastasis of breast and prostate carcinoma
✍ Scribed by Gabriele Carlinfante; Daphne Vassiliou; Olle Svensson; Mikael Wendel; Dick Heinegård; Göran Andersson
- Book ID
- 111550467
- Publisher
- Springer
- Year
- 2003
- Tongue
- English
- Weight
- 263 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0262-0898
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Several human breast cancer cell lines express the calcitonin receptor (CTR), but this has not been demonstrated previously in clinical breast cancers. We examined 18 primary breast cancers by reverse transcription-PCR, for expression of CTR and of the bone proteins osteopontin (OPN) and bone sialop
## Abstract Poor prognosis in mammary carcinoma is associated with a certain expression profile of a defined set of genes including osteopontin and bone sialoprotein. Efficient and specific delivery of antisenses (AS) and a protection of the sequences from degradation are the crucial conditions for