Differential expression of miRNAs in rhabdomyosarcoma and malignant rhabdoid tumor
✍ Scribed by Armeanu-Ebinger, Sorin; Herrmann, Delia; Bonin, Michael; Leuschner, Ivo; Warmann, Steven W.; Fuchs, Jörg; Seitz, Guido
- Book ID
- 118506477
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 940 KB
- Volume
- 318
- Category
- Article
- ISSN
- 0014-4827
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## Abstract The __INI1__ gene, which encodes a functionally uncharacterized protein component of the hSWI/SNF chromatin remodeling complex, is often mutated or deleted in malignant rhabdoid tumor (MRT). Two isoforms of INI1, that differ by the variable inclusion of nine amino acids, potentially are
## Abstract ## BACKGROUND: Atypical teratoid/rhaboid tumors (AT/RTs) and extracranial malignant rhabdoid tumors are highly malignant neoplasms with a dismal prognosis. These tumors predominantly affect infants and targeted, adjuvant treatment approaches would be highly desirable. ## METHODS: In