Differential expression of D-type cyclins and p27 in human gastric cancers
β Scribed by Yu, Jun; Leung, Wai K.; Ng, Enders Kw; Chan, Wing Y.; Go, Minnie Yy; Sung, Joseph Jy
- Book ID
- 123067399
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 190 KB
- Volume
- 118
- Category
- Article
- ISSN
- 0016-5085
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Background and Objectives: p27Kip1 is an inhibitor of cyclindependent kinases and is speculated to be a potential prognostic indicator in numerous human cancers. We investigated expression of p27Kip1 along with cyclin D1 in gastric cancer to estimate the clinical utility of p27Kip1. Methods: Immunoh
D-type cyclins are proto-oncogenic components of the 'RB pathway', a G1/S regulatory mechanism centred around the retinoblastoma tumour suppressor (pRB) implicated in key cellular decisions that control cell proliferation, cell-cycle arrest, quiescence, and differentiation. This study focused on imm