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Differential enhancement of antidepressant penetration into the brain in mice with abcb1ab (mdr1ab) P-Glycoprotein gene disruption

✍ Scribed by Manfred Uhr; Markus T Grauer; Florian Holsboer


Book ID
118509322
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
144 KB
Volume
54
Category
Article
ISSN
0006-3223

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Contribution of the murine mdr1a P-glyco
✍ Johan W. Smit; Alfred H. Schinkel; Michael MΓΌller; Betty Weert; Dirk K. F. Meije πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 129 KB

In the mouse, both the mdr1a and the mdr1b gene encode drug-transporting P-glycoproteins. The mdr1a P-glycoprotein is expressed in epithelial cells of, among others, the liver and the intestine. Furthermore, the mdr1b gene product is found in the liver but is not detectable in the intestine. To esta