Differential effects of vitamin D on normal human prostate epithelial and stromal cells in primary culture
β Scribed by D Krill; J Stoner; B.R Konety; M.J Becich; R.H Getzenberg
- Book ID
- 117265954
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 360 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0090-4295
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## Abstract The vitamin D receptor (VDR) is a member of the steroid/retinoid receptor superfamily of nuclear receptors and has potential tumorβsuppressive functions in prostate and other cancer types. Vitamin D~3~ (VD~3~) exerts its biological actions by binding within cells to VDR. The VDR then in
## Abstract Although many studies have examined the mechanisms of 1,25βdihydroxyvitamin D~3~ (calcitriol or 1,25 D) action in different prostate cancer cell lines, little is known regarding the influence of this steroid on the normal prostate. The presence of both VDR and AR in normal prostatic tis