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Differential effects of stress on presynaptic and postsynaptic 5-hydroxytryptamine-1A receptors in the rat brain: an in vitro electrophysiological study

โœ Scribed by N. Laaris; E. Le Poul; A.M. Laporte; M. Hamon; L. Lanfumey

Book ID
117492854
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
242 KB
Volume
91
Category
Article
ISSN
0306-4522

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Flibanserin (BIMT 17) has been described as a 5-HT 1A agonist with preferential affinity for postsynaptic 5-HT 1A receptors and as a 5-HT 2A antagonist. Indeed, using the forskolin-stimulated cAMP accumulation technique, flibanserin but not the 5-HT 1A agonists buspirone and 8-OH-DPAT had agonistic