Differential effects of specific amino acid restriction on glucose metabolism, reduction/oxidation status and mitochondrial damage in DU145 and PC3 prostate cancer cells

Cell death of prostate cancer cells by s

Cell death of prostate cancer cells by specific amino acid restriction depends on alterations of glucose metabolism

✍ Ya-Min Fu; Huimin Lin; Xiaoyi Liu; Weigang Fang; Gary G. Meadows 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 841 KB

## Abstract Selective amino acid restriction targets mitochondria resulting in DU145 and PC3 prostate cancer cell death. This study shows that restriction of tyrosine and phenylalanine (Tyr/Phe), glutamine (Gln), or methionine (Met) differentially modulates glucose metabolism, glycogen synthase kin