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Differential effects of prolonged high frequency stimulation and of excitotoxic lesion of the subthalamic nucleus on dopamine denervation-induced cellular defects in the rat striatum and globus pallidus

✍ Scribed by Jean-Jacques Bacci; El Hadi Absi; Christine Manrique; Christelle Baunez; Pascal Salin; Lydia Kerkerian-Le Goff


Book ID
109020734
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
566 KB
Volume
20
Category
Article
ISSN
0953-816X

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## Abstract High‐frequency stimulation (HFS) of the subthalamic nucleus (STN) proves to be an efficient treatment for alleviating motor symptoms in Parkinson's disease (PD). However, the mechanisms of HFS underlying these clinical effects remain unknown. Using intracerebral microdialysis, we previo