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Differential effects of proglumide on mesolimbic and nigrostriatal dopamine function

✍ Scribed by J. G. Csernansky; S. Glick; J. Mellentin

Publisher: Springer
Year: 1987
Tongue: English
Weight: 550 KB
Volume: 91
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00216008

No coin nor oath required. For personal study only.

✦ Synopsis

Cholecystokinin octapeptide (CCK-8) is prevalent as a co-transmitter in the mesolimbic dopamine pathway. The effect of proglumide, a CCK-8 antagonist, on two acute and one chronic behavioral models of dopamine function was tested. First, haloperidol was used to inhibit stereotypies induced by apomorphine in rats. Pre-administration of proglumide significantly shifted the haloperidol dose response curve to the left. Second, rats were injected in the left caudate nucleus with kainic acid. Three weeks later, haloperidol was used to inhibit apomorphine-induced circling. Pre-administration of proglumide had no effect on this haloperidol dose response curve. Third, either proglumide, haloperidol, or combined treatment was administered to rats for 2 weeks. In proglumide-treated animals, a significant increase in 3H-spiperone binding sites in the nucleus accumbens was observed.

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