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Differential effects of organometallic tin compounds on Na+/K+-ATPase activity

✍ Scribed by Purnima M. Samuel; Sujit Roy; K. Aradhana Jaiswal; J. Venkateswara Rao

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 82 KB
Volume: 18
Category: Article
ISSN: 0260-437X
DOI: 10.1002/(sici)1099-1263(1998090)18:5<383::aid-jat523>3.0.co;2-0

No coin nor oath required. For personal study only.

✦ Synopsis

In vitro effects of six dibenzyltin dichloride (A-series) and another six dibenzyltin diisothiocyanate (Bseries) complexes on Na ؉ /K ؉ -ATPase were studied. The rat brain synaptic membranes were prepared and significant ATPase inhibition was observed with all the complexes in a dose-dependent manner. The order of potency on Na ؉ /K ؉ -ATPase activity of the chloride complexes was found to be higher than that of the isothiocyanate complexes. The ic 50 values range from 64 M to 252 M for the chloride complexes and from 132 M to 399 M for the isothiocyanate complexes. A structure-activity relationship could be derived for the chloride complexes.

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