Differential effects of nalidixate on the cell growth of respiratory competent strains and cytoplasmic petite mutants of Saccharomyces cerevisiae

✍ Scribed by Carnevali, F. ;Sarcoe, L. E. ;Whittaker, P. A.

• Book ID: 104693329
• Publisher: Springer
• Year: 1976
• Tongue: English
• Weight: 489 KB
• Volume: 146
• Category: Article
• ISSN: 0026-8925
• DOI: 10.1007/bf00267988

✦ Synopsis

Sodium nalidixate inhibited the cell growth and division of several respiratory competent strains of Saccharomyces cerevisiae. A number of cytoplasmic petite strains (both spontaneous and induced by ethidium bromide) were shown to be more resistant to sodium nalidixate than the wild-type strains from which they were derived. There was considerable variation in sensitivity of different petites derived from the same wild-type. Usually petite strains which were induced by ethidium bromide were more resistant than spontaneously arising petites. The susceptibility of a wild-type strain to nalidixate was found to be least when the mitochondrial respiratory system was maximally repressed. It was also noted that sodium nalidixate (100 mug/ml) induced petite mutants.