Differential effects of mutant SOD1 on protein structure of skeletal muscle and spinal cord of familial amyotrophic lateral sclerosis: Role of chaperone network

Oxidative and excitotoxic insults exert

Oxidative and excitotoxic insults exert differential effects on spinal motoneurons and astrocytic glutamate transporters: Implications for the role of astrogliosis in amyotrophic lateral sclerosis

✍ Chrissandra J. Zagami; Philip M. Beart; Nicole Wallis; Phillip Nagley; Ross D. O 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 989 KB

## Abstract In amyotrophic lateral sclerosis (ALS) non‐neuronal cells play key roles in disease etiology and loss of motoneurons via noncell‐autonomous mechanisms. Reactive astrogliosis and dysfunctional transporters for L‐glutamate [excitatory amino acid transporters, (EAATs)] are hallmarks of ALS