𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Differential effects of morphine withdrawal on cerebral β1- and β2-adrenergic receptors

✍ Scribed by Dr. Kinya Kuriyama; Makoto Muramatsu; Seitaro Ohkuma; Jun-Ichi Tamura; Zuo Ping Ping

Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
438 KB
Volume
6
Category
Article
ISSN
0360-4012

No coin nor oath required. For personal study only.

✦ Synopsis

Effect of morphine dependence and its withdrawal on the 3H-dihydroalprenolol (3H-DHA) binding for @-adrenergic receptors, PI and p2, was examined by a computerized analysis of biphasic Hofstee plots. The relative density of PI and /32 receptors in the rat cerebral cortex was found to be approximately 70% and 30%, respectively. In rats rendered dependent on morphine by a subcutaneous implantation of a morphine pellet, the 3H-DHA binding to @ I and p2 receptors was not altered. During the stage of withdrawal induced by administration of naloxone, however, the 3H-DHA binding t o the cerebral particulate fractions was increased, and this increase was due to the increased binding sites in PI but not in 0 2 receptor. On the other hand, the apparent affinities of @, and p2 receptors for atenolol and salbutamol, selective antagonists for 6,and 62-adrenergic receptors, respectively, were not altered under these experimental conditions. These results suggest that an abrupt increase in cerebral @,-receptor binding sites occurs at morphine withdrawal, and the occurrence of such a supersensitivity in cerebral @, receptor may be involved in the exhibition and/or maintenance of the abstinence syndrome in morphine-dependent subjects.

📜 SIMILAR VOLUMES

Existence of functional β1- and β2-adren
Existence of functional β1- and β2-adrenergic receptors on microglia
✍ Kenji F. Tanaka; Haruo Kashima; Hiromi Suzuki; Kenji Ono; Makoto Sawada 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 134 KB

## Abstract We examined the expression and function of β‐adrenergic receptor (β‐AR) subtypes in both isolated primary rat microglia and a rat microglial cell line. RT‐PCR analyses revealed that microglia expressed β~1~‐ and β~2~‐ARs but not β~3~‐ARs, whereas rat primary peritoneal macrophages expre

Association of β-1 and β-2 adrenergic re
Association of β-1 and β-2 adrenergic receptor gene polymorphisms with myocardial infarction
✍ Akin Yilmaz; Mehmet G. Kaya; Ulgen Merdanoglu; Mehmet A. Ergun; Atiye Cengel; Se 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 114 KB

## Abstract Both β~1~‐ and β2‐adrenergic receptors (β~1~‐ and β~2~‐AR) have important roles in heart function mainly in response to catecholamines. Some specific polymorphisms in the β~1~‐ and β~2~‐AR genes, named ADRB1 and ADRB2, respectively, have been implicated in several cardiovascular and non

Adenosine A1 and A2A receptor effects on
Adenosine A1 and A2A receptor effects on G-protein cycling in β-adrenergic stimulated ventricular membranes
✍ Richard A. Fenton; James G. Dobson Jr. 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 169 KB

## Abstract In the heart β~1~‐adrenergic (β1R) and adenosine A~1~ (A1R) and A~2A~ (A2AR) receptors modulate contractile and metabolic function. The interaction between these receptors was investigated at the level of G‐protein cycling by determining the effect of receptor agonists on the binding of