✦ LIBER ✦

Differential effects of methylphenidate andd-amphetamine on stereotyped behavior in the rat

✍ Scribed by Robert Pechnick; David S. Janowsky; Lewis Judd

Publisher: Springer
Year: 1979
Tongue: English
Weight: 481 KB
Volume: 65
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00492220

No coin nor oath required. For personal study only.

✦ Synopsis

Different equimolar doses of d-amphetamine and methylphenidate were compared for their potency in eliciting stereotyped behavior in rats. Although at lower doses d-amphetamine appeared more effective in causing stereotyped gnawing, repetitive body movements, and sniffing, at higher doses methylphenidate at certain times caused a greater incidence of gnawing than did d-amphetamine. Understanding these differences and comparing related biochemical correlates may lead to a better definition of mechanisms underlying psychostimulant effects.

📜 SIMILAR VOLUMES

The role of forebrain dopamine systems i

The role of forebrain dopamine systems in amphetamine induced stereotyped behavior in the rat

✍ Ian Creese; Susan D. Iversen 📂 Article 📅 1974 🏛 Springer 🌐 English ⚖ 733 KB

The caudate nucleus or the tuberculum olfactorium of the rat was lesioned by bilateral stereotaxic injection of 6-hydroxydopamine. The degree of dopamine depletion was assessed by a sensitive regional dopamine assay and revealed severe depletions in the lesioned areas. The locomotor response to a lo

Differential effects of the selective D2

Differential effects of the selective D2-antagonist raclopride in the nucleus accumbens of the rat on spontaneous andd-amphetamine-induced activity

✍ Ruud Boss; Alexander R. Cools; Sven-Ove Ögren 📂 Article 📅 1988 🏛 Springer 🌐 English ⚖ 517 KB

The effect of the D2-antagonist raclopride was investigated in two test situations, which are presumed to involve dopamine (DA) transmission within the nucleus accumbens of the rat. Local injection of d-amphetamine sulphate (10 gg/0.5 gl) produced a marked increase in motor activity, measured as mot

Effects of chlordiazepoxide, ripazepam a

Effects of chlordiazepoxide, ripazepam andd-amphetamine on conditioned acceleration of timing behaviour in rats

✍ D. J. Sanger; D. E. Blackman 📂 Article 📅 1976 🏛 Springer 🌐 English ⚖ 639 KB

The lever-pressing behaviour of three rats was maintained by a schedule in which food reinforcement was obtained by any response which was emitted at least 15 s after the previous response (DRL 15 s). When performance on this schedule had stabilised, the animals were presented intermittently with l-

Some effects of chlordiazepoxide andd-am

Some effects of chlordiazepoxide andd-amphetamine on response force during punished responding in rats

✍ Stephen C. Fowler; A. W. Price 📂 Article 📅 1978 🏛 Springer 🌐 English ⚖ 448 KB

Rats were reinforced with water on a continuous reinforcement schedule and were also punished with electric shock for every fifth response applied to a silent, isometric, force-sensing manipulandum. Oral doses of chlordiazepoxide (3.0, 9.0, 27.0 mg/kg) increased both conventional rate and force of p

Effects of nicotine andd-amphetamine on

Effects of nicotine andd-amphetamine on intracranial self-stimulation in a shuttle box test in rats

✍ P. B. S. Clarke; R. Kumar 📂 Article 📅 1984 🏛 Springer 🌐 English ⚖ 670 KB

Rats were permitted to turn on and off electrical stimulation of the medial forebrain bundle, by alternating between two photobeams running along opposite walls of a shuttle box. Entry into one beam (the "ON" beam) triggered the delivery of a succession of short, regularly occurring (1 Hz) pulse tra

Effect of amphetamine and haloperidol on

Effect of amphetamine and haloperidol on stereotyped behavior in cats during electrical stimulation of the substantia nigra

✍ É. B. Arushanyan; B. A. Tolpyshev 📂 Article 📅 1981 🏛 Springer US 🌐 English ⚖ 428 KB