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Differential effects of kindling and kindled seizures on place learning in the morris water maze

✍ Scribed by Robert K. McNamara; R. Duncan Kirkby; Gregory E. dePape; Ronald W. Skelton; Michael E. Corcoran

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 445 KB
Volume: 3
Category: Article
ISSN: 1050-9631
DOI: 10.1002/hipo.450030207

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✦ Synopsis

There is some controversy about the role of long-term potentiation (LTP) in spatial learning. The authors have found that triggering generalized kindled seizures with stimulation of the perforant path disrupts spatial learning in the Morris water maze but that kindling per se does not affect spatial learning. It is suggested that abnormal electrical activity induced by high-frequency stimulation of the perforant path may have been responsible for the disruption of spatial learning previously attributed to LTP saturation.

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