Sensitivity to insulin in vivo was studied in 8 normal weight C-peptide negative Type 1 (insulin-dependent) diabetic patients (age 23 +/- 1 years, diabetes duration 6 +/- 2 years), and in 8 age, weight and sex matched healthy subjects, using the euglycaemic clamp and 3-3H-glucose tracer technique. P
Differential effects of insulin therapy on hepatic and peripheral insulin sensitivity in Type 2 (non-insulin-dependent) diabetes
β Scribed by A. Nankervis; J. Proietto; P. Aitken; M. Harewood; F. Alford
- Publisher
- Springer
- Year
- 1982
- Tongue
- English
- Weight
- 697 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0012-186X
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Hepatic glucose production (3H-glucose technique) and insulin-mediated glucose uptake (insulin clamp technique) were measured in 38 Type 2 (non-insulin-dependent) and 11 Type 1 (insulin-dependent) diabetic patients. Fasting plasma glucose concentration was 8.3 4-0.5 mmol/1 in the former, and 9.6 + 1
The sodium retaining effect of insulin was studied in ten Type 2 (non-insulin-dependent) diabetic patients (mean age 56 (43-73)years, mean body mass index 29.5 (24.2-33.7) kg/m o and eight age-matched control subjects (mean age 57 (43~58)years, mean body mass index 23.4 (20.8-26.6) kg/m2). The renal