## Abstract The tuftelin protein isoforms undergo post‐translation modifications, and are ubiquitously expressed in various tissues in embryos, adults, and tumors. Developmental and pathological studies suggested an apparent correlation between oxygen deprivation and tuftelin expression. The aim of
Differential effects of hypoxia on untreated and NGF treated PC12 cells
✍ Scribed by Johann Gross; Norbert Leclere; Julia Heldt; Iris Müller; Thomas Kietzmann; Nadja Andreeva
- Book ID
- 117172593
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 106 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0024-3205
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Neuritin is a small, highly conserved GPI‐anchored protein involved in neurite outgrowth. We have analyzed the involvement of neuritin in NGF‐induced differentiation of PC12 cells by investigating the time‐course of neuritin expression, the effects of its overexpression or silencing, an
## Abstract In vivo, the neurotoxin MPTP is oxidated to MPP^+^, which is toxic to dopaminergic neurons. In this paper, we have used MPP^+^ as a tool to evoke neurotoxicity in the PC12 cell line and investigate the intracellular events that are involved. A cytotoxicity test, performed on undifferent
The effects of inhibition of glycosylation on nerve growth factor (NGF) binding and neurite outgrowth response of PC12 cells have been examined. Exposure to tunicamycin (1-10 pgiml) for 24-36 hr eliminates the rapidly dissociating component of NGF binding and decreases the proportion of PC12 cells c
Cytoskeletal proteins have been reported as constituents of cytoplasmic inclusions typical of degenerated neurones in Parkinson's disease and, in addition, the involvement of cytoskeleton in the mechanism of action of the parkinsonism-producing neurotoxin MPP+ is emerging. Here we investigate the in