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Differential effects of histone deacetylase inhibitors on phorbol ester- and TGF-β1 induced murine tissue inhibitor of metalloproteinases-1 gene expression

✍ Scribed by David A. Young; Olivia Billingham; Clara L. Sampieri; Dylan R. Edwards; Ian M. Clark


Book ID
111309941
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
410 KB
Volume
272
Category
Article
ISSN
1432-1327

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## Abstract Transforming growth factor (TGF‐β1) is a potent inducer of chondrogenesis and stimulant of cartilage extracellular matrix (ECM) synthesis. Tissue inhibitor of metalloproteinases‐3 (TIMP‐3) is located in ECM and is the major inhibitor of matrix metalloproteinases (MMPs) and aggrecanase,