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Differential Effects of Ethanol on Insulin-Signaling Through the Insulin Receptor Substrate-1

✍ Scribed by S. M. de la Monte; N. Ganju; S. Tanaka; K. Banerjee; P. J. Karl; N. V. Brown; J. R. Wands


Book ID
109121387
Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
977 KB
Volume
23
Category
Article
ISSN
0145-6008

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## Abstract Translocation of the insulin receptor substrate‐1 (IRS‐1) to the nuclei has been reported to occur in cells stimulated by insulin‐like growth factor‐1 (IGF‐I) or expressing certain viral and cellular oncogenes. We show here that insulin can also induce nuclear translocation of IRS‐1 in