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Differential effects of diazepam treatment and withdrawal on recombinant GABAA receptor expression and functional coupling

✍ Scribed by Dubravka Švob Štrac; Josipa Vlainić; Maja Jazvinšćak Jembrek; Danka Peričić

Book ID
113503895
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
574 KB
Volume
1246
Category
Article
ISSN
0006-8993

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## Abstract Diazepam is widely prescribed as an anxiolytic but its therapeutic application is limited because with daily use tolerance develops to certain aspects of its pharmacological profile. We compared the effects of two dosing paradigms on GABA~A~ receptor gene expression and benzodiazepine b