Effect of pirenzepine on the N-demethyla
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H. A. El-Obeid; K. A. Al-Rashood; H. A. Al-Khamees; K. I. Al-Khamis; M. S. Mian
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Article
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1993
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John Wiley and Sons
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English
โ 301 KB
The possible interaction of pirenzepine with the mixed-function oxidases obtained from phenobarbital-pretreated rabbit microsomes was examined in vitro. Under experimental conditions that did not lead to its own N-demethylation, the drug inhibited the microsomal oxidase systems responsible for the N