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Differential effects of cimetidine and ranitidine on imipramine demethylation and desmethylimipramine hydroxylation by human liver microsomes

โœ Scribed by E. Spina; Y. Koike


Publisher
Springer
Year
1986
Tongue
English
Weight
392 KB
Volume
30
Category
Article
ISSN
0031-6970

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Effect of pirenzepine on the N-demethyla
โœ H. A. El-Obeid; K. A. Al-Rashood; H. A. Al-Khamees; K. I. Al-Khamis; M. S. Mian ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 301 KB

The possible interaction of pirenzepine with the mixed-function oxidases obtained from phenobarbital-pretreated rabbit microsomes was examined in vitro. Under experimental conditions that did not lead to its own N-demethylation, the drug inhibited the microsomal oxidase systems responsible for the N