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Differential effect of APOE 4 allele on Amyloid beta accumulation in Alzheimer's disease and non-Alzheimer's disease

✍ Scribed by Kenji Ishii; Kiichi Ishiwata; Keiichi Oda; Muneyuki Sakata; Masatomo Ishikawa; Kenji Ishibashi; Yuko Saito; Aya Tokumaru; Kazutomi Kanemaru; Shigeo Murayama


Book ID
118465600
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
201 KB
Volume
5
Category
Article
ISSN
1552-5260

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APOE epsilon-4 allele and cytokine produ
✍ Paolo Olgiati; Antonis Politis; Petros Malitas; Diego Albani; Sabrina Dusi; Leti πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 124 KB

## Abstract ## Objective The APOE epsilon‐4 allele has consistently emerged as a susceptibility factor for Alzheimer's disease (AD). Pro‐inflammatory cytokines are detectable at abnormal levels in AD, and are thought to play a pathophysiological role. Animal studies have shown dose‐dependent corre