Differential distribution of basement membrane type IV collagen α1(IV), α2(IV), α5(IV) and α6(IV) chains in colorectal epithelial tumors
✍ Scribed by Yutaka Hiki; Ken-ichi Iyama; Junji Tsuruta; Hiroshi Egami; Takihiro Kamio; Shuji Suko; Ichiro Naito; Yoshikazu Sado; Yoshifumi Ninomiya; Michio Ogawa
- Book ID
- 119740128
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 789 KB
- Volume
- 52
- Category
- Article
- ISSN
- 1320-5463
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Type IV collagen is a major component of vascular basement membranes. The noncollagenous (NC1) domains of several α‐chains of type IV collagen reveal a capacity to inhibit angiogenesis and tumor growth. Here, we demonstrate that the NC1 domain of the α6 chain of type IV collagen (α6NC1)
In vitro binding studies with latent matrix metalloproteinase-9 (pro-MMP-9) have revealed the existence of nondisulfide-bonded alpha2(IV) chains on the cell surface capable of forming a high-affinity complex with the enzyme. Here we investigated the biosynthesis and cellular distribution of alpha2(I