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Differential cytotoxicity and induction of apoptosis in tumor and normal cells by hydroxymethylacylfulvene (HMAF)∗

✍ Scribed by Barbara A Woynarowska; Jan M Woynarowski; Maryanne C.S Herzig; Kari Roberts; Arlene L Higdon; John R MacDonald

Book ID
113992238
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
490 KB
Volume
59
Category
Article
ISSN
0006-2952

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## Abstract A series of geiparvarin analogues modified on the unsaturated alkenyloxy bridge, where a H‐atom replaced the 3′‐Me group, were synthesized and evaluated against a panel of human tumor cell lines __in vitro.__ These compounds demonstrated a stronger increase in growth inhibitory activity