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Differential contribution of C-terminal regions of dermorphin and dermenkephalin to opioid-sites selection and binding potency

✍ Scribed by Sandrine Sagan; Mohamed Amiche; Antoine Delfour; Alain Camus; Amram Mor; Pierre Nicolas


Book ID
115762292
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
342 KB
Volume
163
Category
Article
ISSN
0006-291X

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In this study, we present evidence for the occurrence of p, 6, and K opioid binding sites in synaptic plasma membranes (SPM) and microsomes of rat brain. Binding to all three opioid classes was inhibited by 5'-guanylylimidodiphosphate (Gpp[NH]p) in SPM, while microsomal sites proved to be insensitiv