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Differential antiproliferatve effects of combinations of recombinant interferons alpha and gamma on two murine tumor cell lines

✍ Scribed by Michael J. Brunda; Rosemary B. Wright

Publisher
John Wiley and Sons
Year
1986
Tongue
French
Weight
537 KB
Volume
37
Category
Article
ISSN
0020-7136

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✦ Synopsis

The in vitro antiproliferative effects of recombinant interferons (IFNs) alpha and gamma against the murine reticulumtell sarcoma M5076 and the malignant melanoma 816 FIO were evaluated using the human hybrid IFN-alpha A/D (rHuIFN-a"), which is active on murine cells, and recombinant murine IFN gamma (rMu1FN-y). An isobologram analysis was used to evaluate the interactive antiproliferative effects of the recombinant IFNs on these two tumor cell lines. The data, in contrast to prior reports, indicate that rHulFN-aA/D and rMulFN7 interact in an additive rather than a synergistic manner against M5076 cells. When a similar analysis was performed on 816 FIO cells, synergy was obtained. Thus, either a synergistic or an additive antiproliferative effect can be obtained by combining IFN-u and IFN-y, depending upon the cell line used in the assay.

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