Differential activity of recombinant colony-stimulating factors in supporting proliferation of human peripheral blood and bone marrow myeloid progenitors in culture
β Scribed by Daniele Caracciolo; Steven Clark; Giovanni Rovera
- Book ID
- 114711898
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 560 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0007-1048
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Combinations of low dosages of purified recombinant human (rh) macrophagecolony stimulating factor (M-CSF; also termed CSF-1) and rh granulocyte-colony stimulating factor (G-CSF) were compared alone and in combination for their influence on the cycling rates and numbers of bone marrow and splenic gr
## Abstract The roles of colonyβstimulating factors in longβterm bone marrow cultures were studied and compared. After single additions of high concentrations of unpurified colonyβstimulating activities to the cultures, rapid deterioration of the cultures was observed. This appears to result from c