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Differential activation requirements of isotype-switched B cells

✍ Scribed by Rolf O. Ehrhardt; Gregory R. Harriman; John K. Inman; Nils Lycke; Belinda Gray; Warren Strober

Book ID
102826269
Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
950 KB
Volume
26
Category
Article
ISSN
0014-2980

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## Abstract Isotype switching by B cells is highly regulated by a group of cytokines including IL‐4, IFN‐γ and TGF‐β. A B cell can only express one isotype at a time; however, during an immune response it may be exposed to combinations of stimuli that provide it with conflicting switching instructi