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Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the ‘two hit’ hypothesis

✍ Scribed by Xiongwei Zhu; Rudolph J Castellani; Atsushi Takeda; Akihiko Nunomura; Craig S Atwood; George Perry; Mark A Smith

Book ID: 114096124
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 364 KB
Volume: 123
Category: Article
ISSN: 0047-6374
DOI: 10.1016/s0047-6374(01)00342-6

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## Abstract Two of the earliest manifestations of the selective neurodegeneration that occurs in Alzheimer's disease (AD) involve the oxidative modification of various biomacromolecules and the reexpression of a multitude of cell cycle‐related proteins. Taken together with the proximal and ectopic