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Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the ‘two hit’ hypothesis

✍ Scribed by Xiongwei Zhu; Rudolph J Castellani; Atsushi Takeda; Akihiko Nunomura; Craig S Atwood; George Perry; Mark A Smith


Book ID
114096124
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
364 KB
Volume
123
Category
Article
ISSN
0047-6374

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## Abstract Two of the earliest manifestations of the selective neurodegeneration that occurs in Alzheimer's disease (AD) involve the oxidative modification of various biomacromolecules and the reexpression of a multitude of cell cycle‐related proteins. Taken together with the proximal and ectopic