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Differential actions and excitotoxicity of glutamate agonists on motoneurons in adult mouse cervical spinal cord slices

โœ Scribed by N Hori; Y Tan; M King; N.L Strominger; D.O Carpenter


Book ID
113998662
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
581 KB
Volume
958
Category
Article
ISSN
0006-8993

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## Abstract In amyotrophic lateral sclerosis (ALS) nonโ€neuronal cells play key roles in disease etiology and loss of motoneurons via noncellโ€autonomous mechanisms. Reactive astrogliosis and dysfunctional transporters for Lโ€glutamate [excitatory amino acid transporters, (EAATs)] are hallmarks of ALS