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Different profile and distribution of antigen specific T cells induced by intranasal and intrarectal immunization with rotavirus 2/6-VLP with and without LT-R192G

✍ Scribed by Alkadah, Abdelkarim; Thiam, Fatou; Mounier, Morgane; Charpilienne, Annie; Poncet, Didier; Kohli, Evelyne; Basset, Christelle

Book ID: 121512012
Publisher: Elsevier Science
Year: 2013
Tongue: English
Weight: 642 KB
Volume: 31
Category: Article
ISSN: 0264-410X
DOI: 10.1016/j.vaccine.2013.02.019

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Virus-like particles containing the rotavirus (RV) internal proteins VP2 and VP6 (2/6-VLP) have been shown to induce serum and fecal antibodies as well as protection in mice after intranasal administration with a mutant of E. coli toxin, LT-R192G. To better understand the origin of fecal IgA induced