Different modes in antibiotic action of tritrpticin analogs, cathelicidin-derived Trp-rich and Pro/Arg-rich peptides

Cathelicidin-derived Trp/Pro-rich antimi

Cathelicidin-derived Trp/Pro-rich antimicrobial peptides with lysine peptoid residue (Nlys): therapeutic index and plausible mode of action

✍ Wan Long Zhu; Kyung–Soo Hahm; Song Yub Shin 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 346 KB

## Abstract Recently, we designed a novel cell‐selective antimicrobial peptide (TPk) with intracellular mode of action from Pro → Nlys (Lys peptoid residue) substitution in a noncell‐selective cathelicidin‐derived Trp/Pro‐rich antimicrobial peptide, tritrpticin‐amide (TP; VRRFPWWWPFLRR‐NH~2~) (__Bi