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Different HPMC viscosity grades as coating agents for an oral time and/or site-controlled delivery system: a study on process parameters and in vitro performances

โœ Scribed by M.E Sangalli; A Maroni; A Foppoli; L Zema; F Giordano; A Gazzaniga

Book ID
113591358
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
182 KB
Volume
22
Category
Article
ISSN
0928-0987

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Different HPMC viscosity grades as coati
Different HPMC viscosity grades as coating agents for an oral time and/or site-controlled delivery system: An investigation into the mechanisms governing drug release
โœ L. Zema; A. Maroni; A. Foppoli; L. Palugan; M.E. Sangalli; A. Gazzaniga ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 207 KB

When used as release-controlling coating agents for tableted core-based pulsatile delivery systems, three different hydroxypropyl methylcellulose (HPMC) grades, Methocel 1 E5, E50, and K4M, provided lag phases of varying duration (Methocel 1 K4M > E50 > E5) and a prompt and quantitative model drug r