Different genotypes are responsible for the normal Russell viper venom assays seen in some cases of congenital factor X deficiency
✍ Scribed by Antonio Girolami; Margherita Scapin; Pamela Scarparo; Silvia Vettore
- Book ID
- 101435543
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 231 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0361-8609
No coin nor oath required. For personal study only.
✦ Synopsis
We read with great interest the letter by Ludwig et al. [1] that raised important concerns about the reliability of our published data concerning the negative impact of erythropoiesis-stimulating agents (ESA) on myeloma patients' survival [2]. As we have commented in the discussion of our article [2], it is correct that the lack of balance of strong predictors of outcome between the ESA and the non-ESA group is the major limitation of our study. This drawback was also nicely addressed by David Steensma in the excellent Editorial that accompanies our publication [3]. The two accompanying tables to this response, however, allow us to present some additional data which support our findings. As shown in Table , ESA maintained its detrimental impact on overall survival (OS) in paired groups with accepted prognostic factors for survival in myeloma, such as age, b2 microglobulin (b2M), serum albumin, and hemoglobin (Hb), which were compara-