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Different Effects of Microsomal Enzyme Inducers on the Biliary Excretion of Digoxin1

✍ Scribed by Nevasaari, Kaisu ;Alakare, Birgitta ;Kärki, N. T.


Book ID
114799276
Publisher
Wiley (Blackwell Publishing)
Year
2009
Weight
349 KB
Volume
39
Category
Article
ISSN
0001-6683

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The biliary excretion of 3H-pentacaine and its metabolites was studied in rats pretreated with an inducer or inhibitor of mixed-function oxidases. Over one-fourth (25.8 per cent) of a 2 mg kg-' intraportal dose of 3H-pentacaine was excreted in bile in urethaneanaesthetized control rats within 3 h. T