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Different effects of high extracellular potassium on the action of Dofetilide and Ambasilide

✍ Scribed by Gjini, Viktor; Schreieck, Juergen; Korth, Michael; Schmitt, Claus

Book ID
123193677
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
139 KB
Volume
27
Category
Article
ISSN
1558-3597

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Effects of altered extracellular potassium and pacing cycle length on the class III antiarrhythmic actions of dofetilide (UK-68,798) in guinea-pig papillary muscle
✍ Tao Yang; PΓ₯l M. Tande; David A. Lathrop; Helge Refsum πŸ“‚ Article πŸ“… 1992 πŸ› Springer US 🌐 English βš– 713 KB

The effects of altered extracellular K+ concentrations ([K+]o) and pacing cycle lengths (CLs) on the electrophysiological actions of dofetilide (UK-68,798), a potent class III antiarrhythmic agent, were examined in isolated guinea-pig ventricular papillary muscle. At a normal [K+]o (4 mM) and at CL