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Different Effects of Amitriptyline and Imipramine on the Pharmacokinetics and Metabolism of Perazine in Rats

✍ Scribed by WLADYSLAWA A. DANIEL; MACIEJ SYREK; ANNA HADUCH; JACEK WÓJCIKOWSKI

Book ID
111768595
Publisher
Pharmaceutical Press
Year
2000
Tongue
English
Weight
136 KB
Volume
52
Category
Article
ISSN
2042-7158

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✍ R. Krüger; G. Hölzl; H. J. Kuss; L. Schefold 📂 Article 📅 1986 🏛 Springer 🌐 English ⚖ 879 KB

The metabolism of the tricyclic antidepressants amitriptyline (AMI), imipramine (IMI), chlorimipramine (CMI) and some of their metabolites was studied in vitro in isolated liver microsomes of female Spraque-Dawley rats. Nine metabolites of AMI, seven metabolites of IMI, and 11 metabolites of CMI wer