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Different Effects of 4-Hydroxyproline and 4-Fluoroproline on the Stability of Collagen Triple Helix

✍ Scribed by Nishi, Yoshinori; Uchiyama, Susumu; Doi, Masamitsu; Nishiuchi, Yuji; Nakazawa, Takashi; Ohkubo, Tadayasu; Kobayashi, Yuji


Book ID
125981774
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
148 KB
Volume
44
Category
Article
ISSN
0006-2960

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4-Chloroprolines: Synthesis, conformatio
✍ Matthew D. Shoulders; Ilia A. Guzei; Ronald T. Raines πŸ“‚ Article πŸ“… 2008 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 229 KB

## Abstract Collagen is an abundant, triple‐helical protein comprising three strands of the repeating sequence: Xaa–Yaa–Gly. (2S)‐Proline and (2S,4R)‐4‐hydroxyproline (Hyp) are common in the primary structure of collagen. Here, we use nonnatural proline derivatives to reveal determinants of collage