Different contribution of class II HLA in fulminant and typical autoimmune type 1 diabetes mellitus
β Scribed by A. Imagawa; T. Hanafusa; Y. Uchigata; A. Kanatsuka; E. Kawasaki; T. Kobayashi; A. Shimada; I. Shimizu; T. Maruyama; H. Makino
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 108 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0012-186X
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Several publications have shown that certain alleles at the HLA-DRB1, -DQA1, and -DQB1 loci are associated with insulindependent diabetes mellitus (IDDM). Many of these studies have claimed that HLA-DQβ£1 Arg52 and DQβ€1 Asp57 showed the strongest association with IDDM, but these results could not be
## Abstract Both CD4^+^ and CD8^+^ T lymphocytes play a crucial role in the autoimmune process leading to T1D. Dendritic cells take up foreign antigens and autoantigens; within their endocytic compartments, proteases degrade exogenous antigens for subsequent presentation to CD4^+^ T cells __via__ M