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Different competition of thyroxine binding to transthyretin and thyroxine-binding globulin by hydroxy-PCBs, PCDDs and PCDFs

✍ Scribed by Lans, Martine C.; Spiertz, Cecile; Brouwer, Abraham; Koeman, Jan H.

Book ID: 123417744
Publisher: Elsevier Science
Year: 1994
Tongue: English
Weight: 794 KB
Volume: 270
Category: Article
ISSN: 0926-6917
DOI: 10.1016/0926-6917(94)90054-X

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Previous studies have indicated that chemicals, e.g., hydroxylated polychlorinated biphenyls (PCBs) decrease plasma thyroxin levels through interaction with transthyretin. As a consequence, plasma vitamin A and thyroxin are depleted. Both thyroxin and vitamin A are important regulators of normal epi